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By E. Awtry, et al.,

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J Am Coll Cardiol 2008; 51:679–689. 35 Sohn DW, Kim HK, Park JS, et al. Hemodynamic effects of tachycardia in patients with relaxation abnormality: abnormal stroke volume response as an overlooked mechanism of dyspnea associated with tachycardia in diastolic heart failure. J Am Soc Echocardiogr 2007; 20:171–176. 48 Yu CM, Sanderson JE, Marwick TH, Oh JK. Tissue Doppler imaging a new prognosticator for cardiovascular diseases. J Am Coll Cardiol 2007; 49:1903–1914. 49 Yip GW, Wang M, Wang T, et al.

E. e. massive pulmonary embolus with acute cor pulmonale, RV infarction, postcardiac transplant RV failure and RV failure following left ventricular assist device (LVAD) implantation]. 0268-4705 ß 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Adverse changes in right-sided afterload, preload or right ventricular contractility can result in RV decompensation, first characterized in 1974 [4] as a state of low cardiac output with elevated right-sided (right atrial and central venous) filling pressures.

0b013e328329e9e8 Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. 240 Cardiac failure Figure 1 Septal shift and exaggerated ventricular interdependence in right ventricular dysfunction Figure 2 Effect of increased afterload on right ventricular versus left ventricular function Stroke volume 110 (% of control 100 value) 90 80 70 Right ventricle Left ventricle 60 50 0 Because the RV is constrained by the pericardium (not shown), pathologically increased right ventricular filling pressures are transmitted to the interventricular septum, which shifts towards the LV and distorts the normal geometric relationship between the ventricles.

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