By T. Khan
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Extra resources for Biomarker
If we decide to approximate clinical measurements by a normal curve, we are deciding to use a parametric hyphotesis test. A hypothesis test asks if an effect (difference) exists or not using statistics tests to verify the hypothesis that there is no difference. This is the null hypothesis and designated H0. The hypothesis that contradicts H0 is the alternative hypothesis and written HA. In the null hypothesis we use the words no difference or equal to and in the alternative hypothesis we use the words different from, less than or greater than.
DNA demethylating drugs (DMI), as 24 Biomarker 5-azacytidine and 5-aza-2'-deoxycytidine, have been indicated as a promising new treatment for cancer (Streseman & Lyko, 2008). , 2011). In figure 3, we can see that the epigenetic therapy can “re-programmed” gene expression patterns. Fig. 3. Epigenetic therapy acting in the effects of DNMT or HDAC. Inhibitors of DNMT (DNA methyltransferase) or HDAC (histone deacetylases), as DMI (DNMT inhibitor) and HDI (Histone Deacetylase Inhibitor), respectively, induce the reprogramming expression by chromatin decompression.
Thanos, D. (2002). Deciphering the transcriptional histone acetylation code for a human gene. 111, pp. 381-392. H. & Hokland, P.