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Quantitative Structure–Cytotoxicity Relationship 113 Fig. 6 (Fig. 11, A-8), slightly higher than the optimal logP values reported for derivatives of prenylalcohol, vitamin K2 [26], gallic acid [27] and coumarin [28] (logP of 2–3). W. 210 Length Table 6 Relationship coefficients between CC50 against the indicated cells and each chemical descriptor of 5-trifluoromethyloxazole derivatives 114 M. Ishihara et al. Quantitative Structure–Cytotoxicity Relationship 115 Fig. 12 η–χ diagram of 5-tifluoromethyloxazol derivatives.

463) (Fig. 433) (Fig. 486) (Fig. 15, B-5) (Table 8). 700, respectively (Table 8). 449), but not with other descriptors (Table 8). In HSC-2 and MT-4 cells, there was no clear-cut relationship between CC50 and any descriptors (Table 8). W. 118 M. Ishihara et al. W. 003 Length Surface Volume area range (˚ A) (˚ A2 ) (˚ A3 ) Table 8 Relationship coefficients between CC50 against the indicated cells and each chemical descriptor of 3-formylchromone derivatives Quantitative Structure–Cytotoxicity Relationship 119 120 M.

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