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By Norman K. Hollenberg (ed.)

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The nucleus tractus solitarius in the brainstem is the switchboard that regulates autonomic tone. The nucleus receives and processes incoming signals from the periphery and modulates both the sympathetic and the parasympathetic outflow in an integrated and reciprocal manner. Afferent input from periphery Reciprocal balance between sympathetic and parasympathetic tone 2-7. The central organization of the negative feedback loops in the autonomic nervous system. Inhibitory input from mechanoreceptors in the heart and aortic and carotid baroreceptors travels via afferent vagal fibers to the nucleus tractus solitarius (NTS).

291 . 02) 6 I I ~ Age, y ~ • • -4 • • ~ • . • 10 •• . • • 6- E E Data from 13 randomized trials suggest that sodium restriction has a greater impact on systolic blood pressure than on diastolic pressure. The relationships of blood pressure change induced by salt restriction to both initial blood pressure level and age imply that dietary salt restriction may be most useful in older hypertensive individuals with systolic accentuation of blood pressure [67]. These interventional data support the cross-sectional findings of the INTERSALT study in which salt intake seemed most closely related to the rise in systolic blood pressure associated with age [51,65].

28. : A mutation in the 9. : Genetic association of epithelial sodium channel causing Liddle disease increases channel hypertension and vascular changes in stroke-prone spontaneously activity in the Xenopus laevis oocyte expression system. Proc Natl hypertensive rats. Hypertension 1986, 8:904-910. Acad Sci USA 1995,92:5699-5703. 10. Rapp JP: Characteristics of Dahl salt-susceptible and salt-resistant 29. Lifton RP: Molecular genetics of human blood pressure variation. rats. In Handbook of Hypertension.

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