By Helmut Buschmann, J?rg Holenz, Antonio Párraga, Antoni Torrens, José Miguel Vela, José Luis D?az
Antidepressants and comparable psychiatric medications are an important pharmaceuticals world wide, accounting for a industry quantity of 20 billion US$ according to 12 months. This guide presents a whole and distinct assessment of all at present to be had psychiatric medicines, protecting greater than 250 diverse compounds.
specific beneficial properties include:
* an important info at the chemistry, pharmacology and healing use of a given drug
* a unique structure with margin notes and compound constructions making an allowance for fast and simple entry to the specified information
Written by means of drug builders from the pharmaceutical undefined, novel medicines presently lower than improvement and new equipment of remedy are indexed part through aspect with classical medicines, permitting an immediate comparability of conventional and cutting edge healing approaches.Content:
Chapter 1.1 Introductory and easy features (pages 2–50): Luz Romero, Ana Montero, Begona Fernandez and Jose M. Vela
Chapter 1.2 Clinics (pages 51–110): Rosario Perez?Egea, Victor Perez, Dolors Puigdemont and Enric Alvarez
Chapter 1.3 Pharmacology (pages 111–140): Begona Fernandez, Luz Romero and Ana Montero
Chapter 1.4 Experimental study (pages 141–172): Ana Montero, Begona Fernandez and Luz Romero
Chapter 1.5 Chemistry (pages 173–296): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann
Chapter 2.1 Introductory and uncomplicated features (pages 298–334): Francesc Artigas
Chapter 2.2 Clinics (pages 335–388): Salvador Ros and Francisco Javier Arranz
Chapter 2.3 Pharmacology (pages 389–448): Analia Bortolozzi, Llorenc Diaz?Mataix and Francesc Artigas
Chapter 2.4 Experimental study (pages 449–489): Pau Celada, Anna Castane, Albert Adell and Francesc Artigas
Chapter 2.5 Chemistry (pages 491–616): Antonio Parraga, Jorg Holenz and Helmut Buschmann
Chapter 3.1 Introductory and uncomplicated facets (pages 618–880): Francisca Lopez?Rios, Serafin Gomez?Martin and Antonio Molina?Moreno
Chapter 3.2 Clinics (pages 881–894): Blanca Gutierrez and Jorge Cervilla
Chapter 3.3 Pharmacology (pages 895–922): Jose Manuel Baeyens
Chapter 3.4 Experimental learn (pages 923–949): Enrique Portillo and Jose M. Vela
Chapter 3.5 Chemistry (pages 951–1087): Monica Garca?Loapez, Susana Yenes, Helmut Buschmann and Antoni Torrens
Chapter 4.1 Introductory and uncomplicated features (pages 1090–1103): Javier Burgueno, Rafael Franco and Francisco Ciruela
Chapter 4.2 Clinics (pages 1105–1154): Francisco Javier Arranz and Salvador Ros
Chapter 4.3 Pharmacology (pages 1155–1182): Francisco Ciruela, Rafael Franco and Javier Burgueno
Chapter 4.4 Chemistry (pages 1183–1196): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann
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Additional info for Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application
X Clinical Phase II: Trials with small numbers of patients conducted to identify drug performance characteristics (optimal dosing, administration, key indication). x Clinical Phase III: Pivotal trials conducted with larger patient populations to establish efficacy and provide additional safety information. x Approval: Data is analyzed and submitted for regulatory review. S. submission to the FDA is called an NDA (New Drug Application) or BLA (Biologic License Application); the European submission to the EMEA (European Medicines Evaluation Agency) is called an MAA (Marketing Authorization Application).
Metabolism The term metabolism comprises the entire physical and chemical processes involved in the maintenance and reproduction of life in which nutrients are broken down to generate energy and to give simpler molecules (catabolism) which by themselves may be used to form more complex molecules (anabolism). In case of heterotrophic organisms, the energy evolving from catabolic processes is made available for use by the organism (IUPAC). Me-too drug A me-too drug is a compound that is structurally very similar to already known drugs, with only minor pharmacological differences (IUPAC).
Diagnostic criteria for depression Diagnostic Statistical Manual of Mental Disorders defines a “major depressive episode” as being characterized by at least five of the following nine symptoms: x Depressed or irritable mood x Decreased interest in pleasurable activities and ability to experience pleasure x Significant weight gain or loss (>5% change in a month) x Insomnia or hypersomnia; early-morning awakening x Psychomotor agitation or retardation x Fatigue or loss of energy x Feelings of worthlessness or excessive guilt x Diminished ability to think or concentrate x Recurrent thoughts of death or suicide Each symptom must be evident daily or almost every day for at least 2 weeks.