By Zeljko J. Bosnjak, J. Thomas August, Joseph T. Coyle, M. W. Anders
Every one quantity of Advances in Pharmacology offers a wealthy selection of studies on well timed issues. quantity 31 bargains with the mechanisms of anesthetic activities lower than basic stipulations in addition to pathophysiologic states.
* Covers anesthetics and cardiac function
* Addresses issues of the cardiovascular procedure and linked diseases
* Explains healing and pathophysiological implications
* info reflex law of peripheral circulation
* comprises complete descriptions of the newest methodologies
* Written through the world over famous specialists within the box of anesthesia examine
Read or Download Anesthesia and Cardiovascular Disease, Volume 31 PDF
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Extra resources for Anesthesia and Cardiovascular Disease, Volume 31
19. , and Brooker, G. (1977). Fluoride stimulation of slow Ca2+current in cardiac muscle. J . Mol. Cell. Cardiol. 9, 461-475. 20. , and Hofmann, F. (1982). Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+current. Nature (London) 298, 576-578. 21. , and Sperelakis, N. (1984). Injection of protein kinase inhibitor into cultured heart cells blocks calcium slow channels. A m . J. Physiol. 246, H630-H634. 22. , and Trautwein, W. (1986). On the mechanism of padrenergic regulation of the Ca2+channel in the guinea pig heart.
8Br-CAMP ( I mM) added to the bath produced a small stimulation of I,, (in the continued presence of G-kinase). This action of the cyclic nucleotide was also reversed by washout. The current tracings illustrated correspond to the two time points labeled a and b in the graph. 0 m M Ba2+as the charge camer. (H. Masuda and N. Sperelakis, 1994). lished, 1994). Note that inhibition of basal I,, began within about 90 sec after breaking into the cell. At steady-state inhibition produced by PKG, was reduced to about 31% of control (Fig.
As indicated, in myocardial cells, cAMP and cGMP act in an antagonistic manner, cAMP stimulating and cGMP inhibiting. In contrast, in VSM cells, cAMP and cGMP act in the same direction, both inhibiting Table 111 Effect of Cyclic Nucleotides on Calcium Slow Channels in Muscle" Cyclic nucleotide cAMP cGMP Cardiac muscle Vascular smooth muscle cells Skeletal muscle Stimulation Inhibition Inhibition Inhibition Stimulation Stimulation From bullfrog (Kokate, T. , Heiny, J. A , , and Sperelakis, N. (1993).